落ち込んだ患者におけるトラニルシプロミン効果のパラクロロフェニルアラニン反転

モノアミンオキシダーゼ（MAO）阻害剤であるトラニルシプロミン硫酸に対する抗うつ薬反応を示した入院双極性および単極の内因性抑うつ患者は、比較的小さな用量のパラクロロフェニルアラニン（PCPA）を短時間添加したときに再発した（つまり、うつ病が戻った）。PCPAが同様に三環系薬物、イミプラミン塩酸塩の抗うつ薬効果を逆転させたという我々の発見とともに検討された。

Hospitalized bipolar and unipolar endogenously depressed patients who showed an antidepressant response to the monoamine oxidase (MAO) inhibitor, tranylcypromine sulfate, relapsed (ie, depression returned) when relatively small doses of parachlorophenylalanine (PCPA) were added for brief periods. Considered together with our findings that PCPA similarly reversed the antidepressant effects of the tricyclic drug, imipramine hydrochloride, implications are (1) serotonergic mechanisms are likely involved in the antidepressant effects of both the tricyclic drugs and MAO inhibitors in man and (2) this indolamine may also play a role in the endogenous clinical state of depression.