反応性選択性の原理：有機化学における不可解な神話

一度有機化学の教義であった反応性選択原理（RSP）は、1970年代に侵食され、1980年までに多かれ少なかれ放棄されました。このミニレビューは、なぜ選択性が反応性の増加とともに低下できない理由を示し、RSPの理論的基礎の弱点を強調します。

The reactivity-selectivity principle (RSP), once a tenet of organic chemistry, eroded during the 1970s and was more or less abandoned by 1980. Although it has been clear for more than 25 years that a decrease in selectivity with increasing reactivity can only be expected with certainty if diffusion control is approached, the RSP has survived as an intuitively appealing rule. This Minireview shows why selectivity cannot generally decrease with increasing reactivity and highlights the weaknesses of the theoretical foundations of the RSP.