ヘプシジンと鉄代謝の障害

肝ペプチドホルモンヘプシジンは、鉄吸収とその組織分布の主要な調節因子です。病理学的に増加したヘプシジン濃度は、炎症、慢性腎疾患、一部の癌に関連する貧血など、鉄の制限性貧血を引き起こすか、寄与します。ヘプシジン欠乏症は、遺伝性ヘモクロマトーシスと効果のない赤血球生成において鉄の過負荷をもたらします。ヘプシジン - フェロポルチン軸は、健康と病気における細胞外鉄の恒常性の主要な調節因子であり、鉄障害と貧血の診断と治療の有望な標的です。

The hepatic peptide hormone hepcidin is the principal regulator of iron absorption and its tissue distribution. Pathologically increased hepcidin concentrations cause or contribute to iron-restrictive anemias including anemias associated with inflammation, chronic kidney disease and some cancers. Hepcidin deficiency results in iron overload in hereditary hemochromatosis and ineffective erythropoiesis. The hepcidin-ferroportin axis is the principal regulator of extracellular iron homeostasis in health and disease, and is a promising target for the diagnosis and treatment of iron disorders and anemias.