足首上腕指数が上昇した被験者では、血漿粘度が増加します

目的：末梢動脈閉塞性疾患（PAOD）は、心血管リスクの増加（CVR）と関連しています。最近、下肢動脈の剛性の増加もCVRの増加に関連していることが報告されています。特に、圧縮性動脈が不十分な被験者（PCA）は、PAODの被験者のCVRよりもさらに高いCVRを持っているようです。動脈剛性の増加を決定する際のhemologelology因子の役割に関する限られたデータが利用可能です。私たちの研究は、血液と血漿粘度と足首上腕指数の上昇（ABI）の間の可能性のある関連を調査することを目的としています。 方法：被験者は、心血管疾患スクリーニングキャンペーンの自由生活参加者でした。ABIの範囲1.3-1.4の62人、ABI> 1.4の20人の被験者は、それぞれ124人と40人の対照被験者と一致しました。心血管疾患の危険因子（血圧、血液脂質、グルコース、タバコの喫煙、肥満）は、日常的な方法で評価されました。血液および血漿粘度は、円錐形の粘度計によって測定されました。足首腕骨指数は、動脈剛性の尺度として計算されました。 RESULTS: Compared with controls, who were carefully matched for age, sex and all cardiovascular risk factors, subjects with elevated ABI values had increased levels of plasma viscosity (1.42 ± 0.11 vs. 1.35 ± 0.10 cP, p <  0.001, for subjects with ABI ranging 1.3-1.4, and 1.41 ± 0.10 vs. 1.33 ± 0.10 cP, p <  0.01, for subjects with ABI> 1.4）。血液粘度に違いは観察されませんでした。 結論：本調査は、他の心血管リスク因子とは無関係に、ABI値が上昇した被験者で血漿粘度が増加するという証拠を提供します。この発見は、PCA患者の高いCVRを説明することに貢献します。

OBJECTIVE: Peripheral artery occlusive disease (PAOD) is associated with increased cardiovascular risk (CVR). Recently it has been reported that also the increased stiffness of lower limb arteries is associated with increased CVR. In particular, subjects with poorly compressible arteries (PCA) appear to have a CVR even higher than that of subjects with PAOD. Limited data are available on the role of hemorheological factors in determining increase in arterial stiffness. Our study aimed to investigate possible association between blood and plasma viscosity and elevated ankle brachial index (ABI). METHODS: Subjects were free-living participants to a cardiovascular disease screening campaign. Sixty-two subjects with ABI ranging 1.3-1.4, and 20 with ABI >1.4 were matched with 124 and 40 control subjects, respectively. Cardiovascular disease risk factors (blood pressure, blood lipids, glucose, cigarette smoking, obesity) were evaluated by routine methods. Blood and plasma viscosities were measured by a cone-plate viscometer. Ankle-brachial index was computed as measure of arterial stiffness. RESULTS: Compared with controls, who were carefully matched for age, sex and all cardiovascular risk factors, subjects with elevated ABI values had increased levels of plasma viscosity (1.42 ± 0.11 vs. 1.35 ± 0.10 cP, p <  0.001, for subjects with ABI ranging 1.3-1.4, and 1.41 ± 0.10 vs. 1.33 ± 0.10 cP, p <  0.01, for subjects with ABI >1.4). No difference in blood viscosity was observed. CONCLUSION: The present investigation provides evidence that plasma viscosity is increased in subjects with elevated ABI values, independently of other cardiovascular risk factors. This finding contributes to explain the high CVR of patients with PCA.