高齢者の連想記憶の神経相関：安静状態の機能的MRI研究

健康な高齢者の連想記憶の神経相関は、関連記憶能力と自発的な脳振動の相関を調べることにより調査されました。80人の健康な高齢者が安静時の機能的MRIを受け、ペア共同学習テスト（PALT）を採用しました。低周波変動（ALFF）の振幅と脳全体およびPALTスコアの分数ALFF（FALFF）との相関が計算されました。PARahippocampal Gyrus（PHG）のAlffとFalffの両方によってインデックス付けされた自発的な活動は、連想記憶性能と有意に正の相関があり、PHGが高齢者の連想記憶に重要な役割を果たすことを示唆しています。

The neural correlates of associative memory in healthy older adults were investigated by examining the correlation of associative memory performance with spontaneous brain oscillations. Eighty healthy older adults underwent a resting-state functional MRI and took a paired-associative learning test (PALT). Correlations between the amplitude of low-frequency fluctuations (ALFF) as well as fractional ALFF (fALFF) in the whole brain and PALT scores were calculated. We found that spontaneous activity as indexed by both ALFF and fALFF in the parahippocampal gyrus (PHG) was significantly positively correlated with associative memory performance, suggesting that the PHG plays a critical role in associative memory in older people.