アスタキサンチンによって発揮された抗癌効果の複数のメカニズム

アスタキサンチン（ATX）は、動物および魚の飼料の食品着色剤として米国食品医薬品局（USFDA）によって承認されたキサントフィルカロテノイドです。藻類や水生動物に広く見られ、強力な抗酸化活性を持っています。以前の研究では、ATXは抗酸化特性を備えたものであり、副作用や毒性のないさまざまな疾患の治療薬として有益であることが明らかになりました。さらに、ATXは、in vivoとin vitroの両方のin vitroの両方で、さまざまな癌モデルの両方で前臨床抗腫瘍の有効性も示しています。Several researches have deciphered that ATX exerts its anti-proliferative, anti-apoptosis and anti-invasion influence via different molecules and pathways including signal transducer and activator of transcription 3 (STAT3), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and peroxisome proliferator-activated receptor gamma (PPARγ).したがって、ATXは癌の化学療法剤として大きな期待を示しています。ここでは、癌療法におけるATXの急速に進歩する分野と、ATXの分子標的をレビューします。

Astaxanthin (ATX) is a xanthophyll carotenoid which has been approved by the United States Food and Drug Administration (USFDA) as food colorant in animal and fish feed. It is widely found in algae and aquatic animals and has powerful anti-oxidative activity. Previous studies have revealed that ATX, with its anti-oxidative property, is beneficial as a therapeutic agent for various diseases without any side effects or toxicity. In addition, ATX also shows preclinical anti-tumor efficacy both in vivo and in vitro in various cancer models. Several researches have deciphered that ATX exerts its anti-proliferative, anti-apoptosis and anti-invasion influence via different molecules and pathways including signal transducer and activator of transcription 3 (STAT3), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and peroxisome proliferator-activated receptor gamma (PPARγ). Hence, ATX shows great promise as chemotherapeutic agents in cancer. Here, we review the rapidly advancing field of ATX in cancer therapy as well as some molecular targets of ATX.