慢性再発性多発性骨髄炎：まれな骨格障害

慢性再発性多発性骨髄炎（CRMO）は、未知の病因のまれな非感染性炎症骨疾患です。CRMOは、主に子供や若い青少年の長い骨と脊椎の形而上学に影響を与えます。細菌性骨髄炎に似た骨痛と発熱の再発性エピソードを示しますが、病変の培養は不妊であり、抗生物質療法に反応しません。最初は細菌性骨髄炎の治療を受け、慢性疼痛のための長期抗生物質療法、および下顎および尺骨の腫れのための長期にわたる抗生物質療法を受けたCRMOと診断された3歳の少年の症例を報告します。CRMOは、抗生物質治療に反応しない慢性骨痛と骨髄炎の鑑別診断に留意する必要があります。

Chronic recurrent multifocal osteomyelitis (CRMO) is a rare non-infectious inflammatory bone disease of unknown aetiology. CRMO mainly affects the metaphyses of long bones and spine in children and young adolescents. It presents with recurrent episodes of bone pain and fever, resembling bacterial osteomyelitis, but cultures of lesions are sterile and it is unresponsive to antibiotic therapy. We report a case of a 3-year-old boy diagnosed with CRMO, who was initially treated for bacterial osteomyelitis, and received prolonged antibiotic therapy for chronic pain, and swelling of mandible and ulna. CRMO should be kept in mind in the differential diagnosis of chronic bone pain and osteomyelitis unresponsive to antibiotic treatment.