Di-2-エチルヘキシルフタル酸塩の毒性効果：概要

Di-2-ethylhexyl phthalate (DEHP) is extensively used as a plasticizer in many products, especially medical devices, furniture materials, cosmetics, and personal care products.DEHPはプラスチックに非共有結合されているため、製品の使用、加熱、および/または洗浄後にこれらの製品から浸出します。多くの製品でDEHPの過剰使用により、産業環境やプラスチック廃棄物処理サイトからの放出を通じて環境に入り込み汚染します。DEHPは、毎日吸入、摂取、皮膚接触を通じて身体に入ることができます。これは、その安全性と人間の健康への潜在的な影響についての懸念を引き起こしています。このレビューの主な目的は、内分泌、精巣、卵巣、神経、肝毒性、および心毒性効果の概要を示すことです。

Di-2-ethylhexyl phthalate (DEHP) is extensively used as a plasticizer in many products, especially medical devices, furniture materials, cosmetics, and personal care products. DEHP is noncovalently bound to plastics, and therefore, it will leach out of these products after repeated use, heating, and/or cleaning of the products. Due to the overuse of DEHP in many products, it enters and pollutes the environment through release from industrial settings and plastic waste disposal sites. DEHP can enter the body through inhalation, ingestion, and dermal contact on a daily basis, which has raised some concerns about its safety and its potential effects on human health. The main aim of this review is to give an overview of the endocrine, testicular, ovarian, neural, hepatotoxic, and cardiotoxic effects of DEHP on animal models and humans in vitro and in vivo.