食道扁平上皮乳頭腫から生じるその場での食道扁平上皮癌の症例

扁平上皮乳頭腫は、食道の一般的な良性腫瘍です。乳頭腫の患者は通常無症候性であり、食道腹膜鏡検査中に偶然診断されます。ほとんどの乳頭腫は小さく、鉗子生検で簡単に除去されます。除去後の乳頭腫の再発はまれです。ヒト乳頭腫ウイルス感染は、食道乳頭腫の発症に役割を果たすことになっています。ただし、乳頭腫の悪性形質転換は非常に珍しいです。ここでは、胃食道接合部での食道扁平上皮乳頭腫の悪性形質転換の症例を、in situで扁平上皮細胞癌に報告します。

Squamous papilloma is a common benign tumor of the esophagus. Patients with papilloma are usually asymptomatic, and they are diagnosed incidentally during esophagogastroduodenoscopy. Most papillomas are small and easily removed by forceps biopsy. Recurrence of papilloma after removal is rare. Human papilloma virus infection is supposed to play a role in the development of esophageal papilloma; however, malignant transformation of papilloma is extremely unusual. Here, we report a case of malignant transformation of esophageal squamous papilloma at the gastroesophageal junction into squamous cell carcinoma in situ, which was treated by endoscopic submucosal dissection.