L-NAME誘導性高血圧ラットのクラウセナランシウム果物抽出物の降圧および血管保護効果

酸化ストレスは、高血圧の病態生理において重要な役割を果たすと考えられています。この研究の目的は、クラウセナランシウム（ロール）ワンピー（WP）果物の皮膚が高血圧の進行、内皮機能障害、抗酸化物質の保存を減衰させるかどうかを調べることでした。n（g）（-nitro-l-アルギニンメチルエステル（l-name）誘導高血圧およびラットの酸化ストレスは、4週間、50mg/kg/kg/日の用量でL-Nameを投与され、2週間連続して毎日250または500mg/kgのWPフルーツ抽出物を投与しました。。さらに、血漿マロンダ科レベルは、L-Name処理されたラットで著しく誘導され、GlutathioneレベルもL-NAME投与後に減少しました。高血圧を減衰させ、一酸化窒素の血清レベルにおけるL-NAME誘導抑制を逆転させ、緩和しました内皮機能障害、酸化ストレスの減少、回復した抗酸化グルタチオン。これは、WPフルーツ抽出物が将来の新しい降圧薬としての開発の潜在的な候補であることを示唆しています。

Oxidative stress is considered to play an important role in the pathophysiology of hypertension. The aim of this research was to find out whether Clausena lansium (Lour.) Skeels of Wampee (WP) fruits extract attenuate the progression of high blood pressure, endothelial dysfunction and preservation of antioxidant status with using a nitric oxide synthase (NOS) inhibitor, N(G) (-nitro-L-arginine methyl ester (L-NAME) induced hypertension and oxidative stress in rats. Healthy adult male rats were received L-NAME at dose of 50mg/kg/day in drinking water for 4 weeks and were orally administered 250 or 500mg/kg of an aqueous extract of WP fruits extract daily for 2 consecutive weeks. Quercetin (QC; 25 mg/kg) was served as a positive control. The results showed that arterial blood pressure, vascular superoxide production, and plasma malondialdehyde level were markedly induced in L-NAME treated rats. In addition, serum nitric oxide, and glutathione levels were also reduced after L-NAME administration. However, daily administration with the high dose of WP fruits extract significantly alleviated these deleterious effects by attenuated high blood pressure, reversed the L-NAME-induced suppression in serum levels of nitric oxide, mitigated endothelial dysfunction, reduced oxidative stress and restored antioxidant glutathione. This suggests that WP fruits extract is a potential candidate for the development as a novel antihypertensive agents in the future.