[凍結血漿と新鮮な凍結血漿の間の血漿成分の比較]

目的：冷凍血漿（FP）と新鮮な凍結血漿（FFP）の血漿成分を比較します。 方法：北京赤十字の血液センターからのFPの20サンプルとFFPの20サンプルがランダムに選択されました。Immediately after plasma melting, 12 plasma components including coagulation factor, fibrinolytic system and anticoagulation protein were detected, including activated partial thromboplastin time (APTT), prothrombin time (PT), coagulation factor Ⅷ (FⅧ) activity, coagulation factor Ⅴ (FⅤ) activity, fibrinogen(FIB) level, ADAMTS-13 activity, von Willebrand因子（VWF）活性、D-ディマー（D-Dimer、DD）、フィブリン分解産物（FDP）、抗トロンビン（AT）、プロテインC（PC）、およびプロテインS（PS）。2種類の血漿間のこれらすべての凝固成分を比較して分析しました。 結果：FFPと比較して、FPのAPTTは有意に延長され（T = 3.428、P <0.01）、PTも有意に延長され（Z = -2.140、P <0.05）、Fⅷ活性は低下しました（T = -3.372、P <0.01）が、すべての参照範囲とPS活性はすべてでした。減少（t = -2.458、p ＜0.05）、2つのタイプの血漿（p> 0.05）の間に他の部分に統計的差はありませんでした。 結論：FPはいくつかの疾患の治療にFFPを置き換えることができますが、いくつかの凝固因子と抗凝固タンパク質が不足しています。

OBJECTIVE: To compare the plasma components of frozen plasma (FP) and fresh frozen plasma (FFP). METHODS: Twenty samples of FP and 20 samples of FFP from Beijing Red Cross Blood Center were randomly selected. Immediately after plasma melting, 12 plasma components including coagulation factor, fibrinolytic system and anticoagulation protein were detected, including activated partial thromboplastin time (APTT), prothrombin time (PT), coagulation factor Ⅷ (FⅧ) activity, coagulation factor Ⅴ (FⅤ) activity, fibrinogen(FIB) level, ADAMTS-13 activity, von Willebrand factor(vWF) activity, D-dimer (D-dimer, DD), fibrin degradation products (FDP), antithrombin (AT), protein C (PC), and protein S (PS). All these coagulation components between the two types of plasma were compared and analyzed. RESULTS: Compared with FFP, APTT in FP was significantly prolonged(t=3.428, P<0.01), and PT was also significantly prolonged(z=-2.140, P<0.05), and FⅧ activity was decreased (t=-3.372, P<0.01), but all in the reference range, and PS activity was decreased(t=-2.458，P＜0.05), there was no statistical difference in the other part between two types of plasma(P>0.05). CONCLUSION: FP can substitute FFP in the treatment of some diseases, although it is lack of some coagulation factors and anticoagulation protein.